A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
BACKGROUND: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. METHODS: We determined cardiomyocyte renewal in 52 patients with advanced heart failure, 28 of whom received left ventricular assist device support. We measured the concentration of nuclear bomb test-derived 14C in cardiomyocyte genomic DNA and performed mathematical modeling to establish cardiomyocyte renewal in heart failure with and without LVAD unloading. RESULTS: We show that cardiomyocyte generation is minimal in end-stage heart failure patients at rates 18 to 50× lower compared with the healthy heart. However, patients receiving left ventricle support device therapy, who showed significant functional and structural cardiac improvement, had a >6-fold increase in cardiomyocyte renewal relative to the healthy heart. CONCLUSIONS: Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically.
Details
Original language | English |
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Pages (from-to) | 245-256 |
Number of pages | 12 |
Journal | Circulation |
Volume | 151 |
Issue number | 3 |
Early online date | 21 Nov 2024 |
Publication status | Published - 21 Jan 2025 |
Peer-reviewed | Yes |
External IDs
ORCID | /0000-0003-0137-5106/work/175217732 |
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ORCID | /0000-0003-1065-4107/work/175219914 |
Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- heart failure, heart-assist device, myocytes, cardiac