A kinetic proofreading argument to understand the role of H3K9 trimethylation in phase-separated chromatin states
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Contributors
Abstract
Histone trimethylation on the tail residue H3K9 of nucleosomes is a hallmark of constitutive heterochromatin. The mechanism of how this mark is maintained over cell division cycles remains a topic of ongoing debate. The recent formulation of the polymer-assisted condensation scenario, through which a stable droplet condensate can form as a reaction container for methylation reactions, has offered a novel approach to answer this long-standing question. In this letter, we develop a kinetic proofreading argument for histone tail methylation that builds on the polymer-assisted condensation model and yields support to the idea that liquid-liquid phase separation underlies the reconstitution of heterochromatin over cell division cycles.
Details
| Original language | English |
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| Pages (from-to) | 1207-1210 |
| Number of pages | 4 |
| Journal | Biophysical journal |
| Volume | 125 |
| Issue number | 5 |
| Publication status | Published - 3 Mar 2026 |
| Peer-reviewed | Yes |
External IDs
| PubMed | 41668372 |
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