A kinetic proofreading argument to understand the role of H3K9 trimethylation in phase-separated chromatin states
Publikation: Beitrag in Fachzeitschrift › Forschungsartikel › Beigetragen › Begutachtung
Beitragende
Abstract
Histone trimethylation on the tail residue H3K9 of nucleosomes is a hallmark of constitutive heterochromatin. The mechanism of how this mark is maintained over cell division cycles remains a topic of ongoing debate. The recent formulation of the polymer-assisted condensation scenario, through which a stable droplet condensate can form as a reaction container for methylation reactions, has offered a novel approach to answer this long-standing question. In this letter, we develop a kinetic proofreading argument for histone tail methylation that builds on the polymer-assisted condensation model and yields support to the idea that liquid-liquid phase separation underlies the reconstitution of heterochromatin over cell division cycles.
Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1207-1210 |
| Seitenumfang | 4 |
| Fachzeitschrift | Biophysical journal |
| Jahrgang | 125 |
| Ausgabenummer | 5 |
| Publikationsstatus | Veröffentlicht - 3 März 2026 |
| Peer-Review-Status | Ja |
Externe IDs
| PubMed | 41668372 |
|---|