A functional hypothesis for adult hippocampal neurogenesis: Avoidance of catastrophic interference in the dentate gyrus

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Laurenz Wiskott - , Humboldt University of Berlin (Author)
  • Malte J. Rasch - , Humboldt University of Berlin, Graz University of Technology (Author)
  • Gerd Kempermann - , Chair of Genomics of Regeneration, Max Delbrück Center for Molecular Medicine (MDC), Volkswagen Foundation, Charité – Universitätsmedizin Berlin (Author)

Abstract

The dentate gyrus is part of the hippocampal memory system and special in that it generates new neurons throughout life. Here we discuss the question of what the functional role of these new neurons might be. Our hypothesis is that they help the dentate gyrus to avoid the problem of catastrophic interference when adapting to new environments. We assume that old neurons are rather stable and preserve an optimal encoding learned for known environments while new neurons are plastic to adapt to those features that are qualitatively new in a new environment. A simple network simulation demonstrates that adding new plastic neurons is indeed a successful strategy for adaptation without catastrophic interference.

Details

Original languageEnglish
Pages (from-to)329-343
Number of pages15
JournalHippocampus
Volume16
Issue number3
Publication statusPublished - 2006
Peer-reviewedYes

External IDs

PubMed 16435309
ORCID /0000-0002-5304-4061/work/161408186

Keywords

ASJC Scopus subject areas

Keywords

  • Adaptation, Autoencoder network, Hippocampus, Network model