A functional hypothesis for adult hippocampal neurogenesis: Avoidance of catastrophic interference in the dentate gyrus

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Laurenz Wiskott - , Humboldt-Universität zu Berlin (Autor:in)
  • Malte J. Rasch - , Humboldt-Universität zu Berlin, Technische Universität Graz (Autor:in)
  • Gerd Kempermann - , Professur für Regenerationsgenomik, Max-Delbrück-Centrum für Molekulare Medizin (MDC), Volkswagenstiftung, Charité – Universitätsmedizin Berlin (Autor:in)

Abstract

The dentate gyrus is part of the hippocampal memory system and special in that it generates new neurons throughout life. Here we discuss the question of what the functional role of these new neurons might be. Our hypothesis is that they help the dentate gyrus to avoid the problem of catastrophic interference when adapting to new environments. We assume that old neurons are rather stable and preserve an optimal encoding learned for known environments while new neurons are plastic to adapt to those features that are qualitatively new in a new environment. A simple network simulation demonstrates that adding new plastic neurons is indeed a successful strategy for adaptation without catastrophic interference.

Details

OriginalspracheEnglisch
Seiten (von - bis)329-343
Seitenumfang15
FachzeitschriftHippocampus
Jahrgang16
Ausgabenummer3
PublikationsstatusVeröffentlicht - 2006
Peer-Review-StatusJa

Externe IDs

PubMed 16435309
ORCID /0000-0002-5304-4061/work/161408186

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • Adaptation, Autoencoder network, Hippocampus, Network model