3-Dimensional Reconstruction From Histopathological Sections: A Systematic Review
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Although pathological tissue analysis is typically performed on single 2-dimensional (2D) histologic reference slides, 3-dimensional (3D) reconstruction from a sequence of histologic sections could provide novel opportunities for spatial analysis of the extracted tissue. In this review, we analyze recent works published after 2018 and report information on the extracted tissue types, the section thickness, and the number of sections used for reconstruction. By analyzing the technological requirements for 3D reconstruction, we observe that software tools exist, both free and commercial, which include the functionality to perform 3D reconstruction from a sequence of histologic images. Through the analysis of the most recent works, we provide an overview of the workflows and tools that are currently used for 3D reconstruction from histologic sections and address points for future work, such as a missing common file format or computer-aided analysis of the reconstructed model.
Details
Original language | English |
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Article number | 102049 |
Number of pages | 6 |
Journal | Laboratory investigation |
Volume | 104 (2024) |
Issue number | 6 |
Early online date | 9 Mar 2024 |
Publication status | Published - Jun 2024 |
Peer-reviewed | Yes |
External IDs
PubMed | 38513977 |
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Keywords
ASJC Scopus subject areas
Keywords
- 3D reconstruction, histology, image alignment, image registration, whole slide image, Animals, Imaging, Three-Dimensional/methods, Humans, Software