3-Dimensional Reconstruction From Histopathological Sections: A Systematic Review

Publikation: Beitrag in FachzeitschriftÜbersichtsartikel (Review)BeigetragenBegutachtung

Beitragende

  • Alexander Kurz - , Deutsches Krebsforschungszentrum (DKFZ) (Autor:in)
  • Heimo Müller - , Medizinische Universität Graz (Autor:in)
  • Jakob N. Kather - , Else Kröner Fresenius Zentrum für Digitale Gesundheit (Autor:in)
  • Lucas Schneider - , Deutsches Krebsforschungszentrum (DKFZ) (Autor:in)
  • Tabea C. Bucher - , Deutsches Krebsforschungszentrum (DKFZ) (Autor:in)
  • Titus J. Brinker - , Deutsches Krebsforschungszentrum (DKFZ) (Autor:in)

Abstract

Although pathological tissue analysis is typically performed on single 2-dimensional (2D) histologic reference slides, 3-dimensional (3D) reconstruction from a sequence of histologic sections could provide novel opportunities for spatial analysis of the extracted tissue. In this review, we analyze recent works published after 2018 and report information on the extracted tissue types, the section thickness, and the number of sections used for reconstruction. By analyzing the technological requirements for 3D reconstruction, we observe that software tools exist, both free and commercial, which include the functionality to perform 3D reconstruction from a sequence of histologic images. Through the analysis of the most recent works, we provide an overview of the workflows and tools that are currently used for 3D reconstruction from histologic sections and address points for future work, such as a missing common file format or computer-aided analysis of the reconstructed model.

Details

OriginalspracheEnglisch
Aufsatznummer102049
Seitenumfang6
FachzeitschriftLaboratory investigation
Jahrgang104 (2024)
Ausgabenummer6
Frühes Online-Datum9 März 2024
PublikationsstatusVeröffentlicht - Juni 2024
Peer-Review-StatusJa

Externe IDs

PubMed 38513977

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • 3D reconstruction, histology, image alignment, image registration, whole slide image, Animals, Imaging, Three-Dimensional/methods, Humans, Software