3D plotting of silica/collagen xerogel granules in an alginate matrix for tissue-engineered bone implants

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

Today, materials designed for bone regeneration are requested to be degradable and resorbable, bioactive, porous, and osteoconductive, as well as to be an active player in the bone-remodeling process. Multiphasic silica/collagen Xerogels were shown, earlier, to meet these require-ments. The aim of the present study was to use these excellent material properties of silica/collagen Xerogels and to process them by additive manufacturing, in this case 3D plotting, to generate implants matching patient specific shapes of fractures or lesions. The concept is to have Xerogel granules as active major components embedded, to a large proportion, in a matrix that binds the granules in the scaffold. By using viscoelastic alginate as matrix, pastes of Xerogel granules were processed via 3D plotting. Moreover, alginate concentration was shown to be the key to a high content of irregularly shaped Xerogel granules embedded in a minimum of matrix phase. Both the alginate matrix and Xerogel granules were also shown to influence viscoelastic behavior of the paste, as well as the dimensionally stability of the scaffolds. In conclusion, 3D plotting of Xerogel granules was successfully established by using viscoelastic properties of alginate as matrix phase.

Details

Original languageEnglish
Article number830
Pages (from-to)1-12
Number of pages12
JournalMaterials
Volume14
Issue number4
Publication statusPublished - 9 Feb 2021
Peer-reviewedYes

External IDs

Scopus 85100914318
ORCID /0000-0003-0423-4093/work/142239568

Keywords

Research priority areas of TU Dresden

ASJC Scopus subject areas

Keywords

  • Additive manufacturing, Biomaterial ink, Rheology, Silica/collagen composite, Tissue-engineered bone implant