Polyacrylamide gels containing ionized functional groups for the molecular imprinting of human growth hormone

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Rimantas Kublickas - (Autor:in)
  • Carsten Werner - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • Giedre Jariene - (Autor:in)
  • Brigitte Voit - , Leibniz Institute of Polymer Research Dresden (Autor:in)
  • Liudvikas Lasas - (Autor:in)

Abstract

Networks of polyacrylamide having methacrylic acid and 2-(dimethylamino)ethyl methacrylate incorporated were studied for the possibility of imprinting human growth hormone. Two templates - the monomeric and the dimeric molecular forms of human growth hormone hormone - were for the first time imprinted using a hydrogel containing charged functional groups. The results show that approximately 90% (w/w) of the templates could be extracted from the molecularly imprinted acrylamide polymers. The molecularly imprinted polymer adsorbed approximately 70 times (for the monomeric form of the hormone) and 60 times (for the dimeric form) more of the template than of the non-imprinted polymer. The selectivity of the molecularly imprinted polymers was also studied.

Details

OriginalspracheEnglisch
Seiten (von - bis)611-617
Seitenumfang7
FachzeitschriftPolymer bulletin
Jahrgang58
Ausgabenummer3
PublikationsstatusVeröffentlicht - März 2007
Peer-Review-StatusJa
Extern publiziertJa

Externe IDs

Scopus 33846609612
ORCID /0000-0002-4531-691X/work/148607744
ORCID /0000-0003-0189-3448/work/159607205

Schlagworte

Schlagwörter

  • Polymer particles, Recognition, Peptides, Lysozyme, Sites