Novel Mutations Including Deletions of the Entire OFD1 Gene in 30 Families with Type 1 Orofaciodigital Syndrome: A Study of the Extensive Clinical Variability

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

  • Izak J. Bisschoff - , Universitätsklinikum Freiburg (Autor:in)
  • Christine Zeschnigk - , Universitätsklinikum Freiburg (Autor:in)
  • Denise Horn - , Charité – Universitätsmedizin Berlin (Autor:in)
  • Brigitte Wellek - , Universitätsmedizin Mainz (Autor:in)
  • Angelika Rieß - , Universitätsklinikum Tübingen (Autor:in)
  • Maja Wessels - , Erasmus University Rotterdam (Autor:in)
  • Patrick Willems - , GENDIA (Autor:in)
  • Peter Jensen - , Universität Aarhus (Autor:in)
  • Andreas Busche - , Universitätsklinikum Freiburg (Autor:in)
  • Jens Bekkebraten - , Visby Hospital (Autor:in)
  • Maya Chopra - , Sydney Children's Hospital (Autor:in)
  • Hanne Dahlgaard Hove - , Universität Kopenhagen (Autor:in)
  • Christina Evers - , Universität Heidelberg (Autor:in)
  • Ketil Heimdal - , University of Oslo (Autor:in)
  • Ann Sophie Kaiser - , Universitätsklinikum Freiburg (Autor:in)
  • Erdmut Kunstmann - , Julius-Maximilians-Universität Würzburg (Autor:in)
  • Kristina Lagerstedt Robinson - , Karolinska Institutet (Autor:in)
  • Maja Linné - , Mitteldeutscher Praxisverbund Humangenetik (Autor:in)
  • Patricia Martin - , Centro de Análisis Genéticos (Autor:in)
  • James McGrath - , Yale University (Autor:in)
  • Winnie Pradel - , Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Katrina E. Prescott - , University of Oslo (Autor:in)
  • Bernd Roesler - , Universitätsklinikum Freiburg (Autor:in)
  • Gorazd Rudolf - , University Medical Centre Ljubljana (Autor:in)
  • Ulrike Siebers-Renelt - , Westfälische Wilhelms-Universität Münster (Autor:in)
  • Nataliya Tyshchenko - , Institut für Klinische Genetik, Universitätsklinikum Carl Gustav Carus Dresden (Autor:in)
  • Dagmar Wieczorek - , Universität Duisburg-Essen (Autor:in)
  • Gerhard Wolff - , Universitätsklinikum Freiburg (Autor:in)
  • William B. Dobyns - , Children's Hospital and Regional Medical Center Seattle (Autor:in)
  • Deborah J. Morris-Rosendahl - , Universitätsklinikum Freiburg (Autor:in)

Abstract

OFD1, now recognized as a ciliopathy, is characterized by malformations of the face, oral cavity and digits, and is transmitted as an X-linked condition with lethality in males. Mutations in OFD1 also cause X-linked Joubert syndrome (JBTS10) and Simpson-Golabi-Behmel syndrome type 2 (SGBS2). We have studied 55 sporadic and six familial cases of suspected OFD1. Comprehensive mutation analysis in OFD1 revealed mutations in 37 female patients from 30 families; 22 mutations have not been previously described including two heterozygous deletions spanning OFD1 and neighbouring genes. Analysis of clinical findings in patients with mutations revealed that oral features are the most reliable diagnostic criteria. A first, detailed evaluation of brain MRIs from seven patients with cognitive defects illustrated extensive variability with the complete brain phenotype consisting of complete agenesis of the corpus callosum, large single or multiple interhemispheric cysts, striking cortical infolding of gyri, ventriculomegaly, mild molar tooth malformation and moderate to severe cerebellar vermis hypoplasia. Although the OFD1 gene apparently escapes X-inactivation, skewed inactivation was observed in seven of 14 patients. The direction of skewing did not correlate with disease severity, reinforcing the hypothesis that additional factors contribute to the extensive intrafamilial variability.

Details

OriginalspracheEnglisch
Seiten (von - bis)237-247
Seitenumfang11
FachzeitschriftHuman mutation
Jahrgang34
Ausgabenummer1
PublikationsstatusVeröffentlicht - Jan. 2013
Peer-Review-StatusJa

Externe IDs

PubMed 23033313

Schlagworte

ASJC Scopus Sachgebiete

Schlagwörter

  • Ciliopathy, OFD1 mutation, Orofaciodigital syndrome