This research demonstrates the potential of using localized, variable axial Tailored Fibre Placement (TFP) reinforcements to mitigate stress concentrations around lateral openings in (aerodynamic shaped) pressure vessels (e.g. for hydrogen storage). The study introduces a virtual-physical design process to develop a methodology for the conception and design of these structural reinforcements. Starting with the design of a suitable laminate structure for high pressure tanks, a representative layer sequence is derived for tube specimens corresponding to the element level. Verification of the developed finite element (FE) models and the design approach is carried out by pressure testing on actual tubes under pressure vessel loading conditions using water or oil. This approach integrates advanced materials engineering concepts with practical testing and represents a comprehensive strategy for improving the structural integrity of high pressure systems.