High proportions of supplementary cementitious materials (SCMs) lead in blended cements to dilutive effects, resulting in less dense microstructure and thus impairing mechanical performance. This study delves into the extent of recovery occurring over time in diverse limestone calcined clay cement (LC3) binders featuring varying substitution levels of Portland cement (PC), primarily incorporating low-grade calcined clay and limestone. The study reveals that between 7 and 28 days, the intricate physicochemical interplay among PC-limestone-metakaolin-gypsum fosters a noteworthy restoration of properties compromised by dilutive effects, despite employing lower-grade SCMs. The filler effect of calcined clay and its pozzolanic attributes enabled significant refinement in pore structure in comparison to pure PC. The characteristic synergetic reactions inherent to LC3 were evident in all blends, irrespective of the extent of clinker content reduction. These reactions encompass the interaction of alumina from metakaolin with sulfates and carbonates, leading to the formation of additional ettringite and monocarboaluminate phases, consequently improving the mechanical strength of the blended systems.