Endoscopic optical coherence tomography device for forward imaging with broad field of view

Publikation: Beitrag in FachzeitschriftForschungsartikelBeigetragenBegutachtung

Beitragende

Abstract

One current challenge of studying human tympanic membranes (TM) with optical coherence tomography (OCT) is the implementation of optics that avoid direct contact with the inflamed tissue. At the moment, no commercial device is available. We report an optics design for contactless forward imaging endoscopic optical coherence tomography (EOCT) with a large working distance (WD) and a broad field of view (FOV) by restricting the overall diameter of the probe to be small (3.5 mm), ensuring a sufficient numerical aperture. Our system uses a gradient-index (GRIN) relay lens and a GRIN objective lens, and executes a fan-shaped optical scanning pattern. The WD and FOV can be adjusted by manually changing the distance between the triplet and the GRIN relay lens. The measured lateral resolution is ∼28 μm at a WD of 10 mm with a FOV of 10 mm. Additionally, a camera and an illumination beam path were implemented within the probe for image guidance during investigations of the TM. We demonstrated the performance of the EOCT design by 3-D imaging of a human TM ex vivo and in vivo with a k-linear spectral domain OCT system.

Details

OriginalspracheEnglisch
Aufsatznummer071302
FachzeitschriftJournal of Biomedical Optics
Jahrgang17
Ausgabenummer7
PublikationsstatusVeröffentlicht - Juli 2012
Peer-Review-StatusJa

Externe IDs

Scopus 84872030095
PubMed 22894463
ORCID /0000-0003-0554-2178/work/142249768
ORCID /0000-0003-2292-5533/work/142256540

Schlagworte

Schlagwörter

  • Endoscopic optical coherence tomography, Field of view, Gradient index, Tympanic membrane