The hot deformation behavior of a Ti–5Al–5Mo–5V–3Cr alloy obtained by the Blended Elemental Powder Metallurgy approach was studied. Hot compression tests were performed to determine the stress–strain relationships at temperatures ranging from 800 °C to 1000 °C and strain rates between 0.1 and 20 s⁻¹. Based on the collected data, a constitutive model was developed using an Arrhenius-type equation, and a deformation activation energy map was generated. Processing maps were created using the Dynamic Material Model theory, and a processing window indicating the optimal hot deformation parameters was determined at temperatures between 900 °C and 1000 °C and strain rates of 0.1–2.0 s⁻¹. Microstructure observations confirmed the results of the DMM analysis, with a homogeneous and recrystallized microstructure found under the processing window parameters. The hot-rolling process was designed using FEM modeling and was successfully verified by laboratory tests. The hot-rolling parameters selected based on previous analysis resulted in a fully compacted material with controlled microstructure. The relationship between the deformation parameters, microstructure, hardness, and tensile properties of the Ti–5Al–5Mo–5V–3Cr alloy after hot rolling was analyzed. Hot rolling using the developed thermomechanical parameters resulted in a significant increase in tensile strength from 757 to 1009 MPa. In general, this study provides a comprehensive characterization of the hot deformation behavior of the Ti–5Al–5Mo–5V–3Cr alloy and valuable insights for optimizing its hot-processing parameters.