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Prof. Federico Calegari

Person

Research interests

All neurons in the brain are generated by neural stem cells (NSC). Neurogenesis mostly occurs during embryonic development and, in certain brain areas, also throughout life. Our goal is to understand the mechanisms controlling the expansion of NSC and their switch to neurogenesis. This is important to understand how the brain forms during development and how does it work throughout life. Not least, controlling neurogenesis can provide us with the means to use NSC to rescue brain deficits associated to aging or disease. Continue reading if you want to know the hidden secrets of our work…

Career

Education

2001

PhD Laboratory of Dr. Patrizia Rosa, CNR-Center of Cellular Pharmacology, Milan, Italy

1998  

B.Sc. and master Università Statale di Milano, Milan, Italy. Course in Biology

Positions held

since 2014  

TUD Professor for Proliferation of Mammalian Neural Stem Cells, Center for Regenerative Therapies (CRTD) and Center for Molecular and Cellular Bioengineering (CMCB), TU Dresden, Germany

2007– 2014

Group leader DFG-Center and Cluster of Excellence for Regenerative Therapies Dresden, Germany

2004– 2006

Staff scientist, Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden, Germany

2001– 2004

Post-doctoral fellow Laboratory of Prof. Wieland Huttner, Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Dresden

Patents

2011   

Methods and compositions for the expansion of somatic stem cells and progenitor cells. EP10160288.6 Artegiani, Grinenko, Waskow and Calegari

2003

Method of interfering with gene expression in mammalian postimplantation embryos G2447US/CA/AU/EP 1305303GTM Calegari, Haubensak, Buchholz and Huttner

Identification Numbers

Scopus author ID 6602353014
Researcher ID A-2422-2009

Related content

De novo identification of universal cell mechanics gene signatures

Urbanska, M., Ge, Y., Winzi, M., Abuhattum, S., Ali, S. S., Herbig, M. & Kräter, M. & 10 others, Toepfner, N., Durgan, J., Florey, O., Dori, M., Calegari, F., Lolo, F. N., Ángel Del Pozo, M., Taubenberger, A., Cannistraci, C. V. & Guck, J., 17 Feb 2025, In: eLife. 12

Research output: Contribution to journalResearch articleContributedpeer-review

Characterization of alternative splicing during mammalian brain development reveals the extent of isoform diversity and potential effects on protein structural changes

Abdullah Alieh, L. H., De Toledo, B. C., Hadarovich, A., Toth-Petroczy, A. & Calegari, F., Oct 2024, In: Biology open. 13, 10, bio061721.

Research output: Contribution to journalResearch articleContributedpeer-review

Manipulation of the nuclear envelope-associated protein SLAP during mammalian brain development affects cortical lamination and exploratory behavior

Mestres, I., Atabay, A., Escolano, J. C., Arndt, S., Schmidtke, K., Einsiedel, M. & Patsonis, M. & 5 others, Bolanõs-Castro, L. A., Yun, M., Bernhardt, N., Taubenberger, A. & Calegari, F., 11 Mar 2024, In: Biology open. 13 (2024), 3, 12 p., bio060359.

Research output: Contribution to journalResearch articleContributedpeer-review

Sharpening the blades of the dentate gyrus: how adult-born neurons differentially modulate diverse aspects of hippocampal learning and memory

Berdugo-Vega, G., Dhingra, S. & Calegari, F., 15 Nov 2023, In: The EMBO journal. 42, 22, e113524.

Research output: Contribution to journalReview articleContributedpeer-review

4931414P19Rik, a microglia chemoattractant secreted by neural progenitors, modulates neuronal migration during corticogenesis

Mestres Lascano, I. & Calegari, F., 1 May 2023, In: Development (Cambridge, England). 150, 9, dev201574.

Research output: Contribution to journalResearch articleContributedpeer-review