Zwillingsschwangerschaft und schwere obstruktive Schlafapnoe

Research output: Contribution to journalCase reportContributedpeer-review



Obstructive sleep apnea during pregnancy, associated with arterial hypertension, pre-eclampsia and adverse outcome of the newborn, has been described. Usually it can successfully be treated with non-invasive ventilation. A 36-year-old, twin-pregnant woman at 28 + 6 weeks of gestation presented with the complaints of snoring and nocturnal oxygen desaturations. Polysomnography confirmed the diagnosis of severe obstructive sleep apnea (respiratory disturbance index [RDI] 104/h, minimal oxygen saturation in pulse oximetry [SpO2/min] 75%). First therapeutic approaches including oxygen supplementation, non-invasive ventilation with continuous positive airway pressure (CPAP) or bilevel positive airway pressure--spontaneous (BiPAP-S) remained without success. Only after ventilation with bilevel positive airway pressure in spontaneous/timed modus (BiPAP-ST) combined with additional oxygen supplementation a satisfactory treatment result could be achieved (RDI 32/h, SpO2/min 85%). Because of progressive pre-eclampsia despite therapy at 31 + 0 weeks of gestation cesarean section was performed and 2 healthy children were delivered. After surgery non-invasive ventilation had to be continued for another six weeks before the condition improved. In contrast to the documented benefits of non-invasive positive pressure ventilation in pregnant women the literature, in our case even with sufficient therapy of sleep apnea progressive pre-eclampsia and premature delivery could not be prevented. Possible explanations include the short treatment duration and existence of twin pregnancy.

Translated title of the contribution
Twin pregnancy and severe obstructive sleep apnea


Original languageGerman
Pages (from-to)93-7
Number of pages5
JournalZeitschrift fur Geburtshilfe und Neonatologie
Issue number2
Publication statusPublished - Apr 2007

External IDs

PubMed 17486532
ORCID /0000-0001-6022-6827/work/127322201
Scopus 34547466557



  • Adult, Cesarean Section, Female, Humans, Infant, Newborn, Infant, Premature, Male, Oxygen Inhalation Therapy, Polysomnography, Positive-Pressure Respiration/methods, Pre-Eclampsia/diagnosis, Pregnancy, Pregnancy Complications/diagnosis, Pregnancy, Multiple, Sleep Apnea, Obstructive/diagnosis