Within-person trial-to-trial variability precedes and predicts cognitive decline in old and very old age: Longitudinal data from the Berlin Aging Study
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Neurocomputational modeling and empirical evidence suggest that losses in neuronal signaling fidelity cause senescent changes in behavior. We applied structural equation modeling to five-occasion 13-year longitudinal data from the Berlin Aging Study (n = 447; age range at t1 = 70-102 years) to test whether trial-to-trial reaction time variability in perceptual speed (identical pictures) antecedes and signals longitudinal decline in levels of performance on perceptual speed (digit letter and identical pictures) and ideational fluency (category fluency). Higher trial-to-trial variability preceded and predicted greater cognitive decline in perceptual speed and ideational fluency. We conclude that trial-to-trial variability signals impending decline in cognitive performance, and that theories of neurocognitive aging need to postulate developmental cascades between senescent changes in variability and central tendency.
Details
Original language | English |
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Pages (from-to) | 2827-2838 |
Number of pages | 12 |
Journal | Neuropsychologia |
Volume | 45 |
Issue number | 12 |
Publication status | Published - 2007 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 17575988 |
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ORCID | /0000-0001-8409-5390/work/142254949 |
Keywords
ASJC Scopus subject areas
Keywords
- Cognitive control, Inconsistency, Longitudinal change, Neurocognitive aging, Neuronal noise, Within-person variability