Single item rating scales, ranging from 0 to 10, are widely utilized in research and clinical practice to provide quick, reliable assessments of constructs such as mood, quality of life, and immune fitness. These scales offer several practical advantages, including ease of administration, reduced patient burden, and straightforward interpretability. This expert opinion explores the distinction between statistical significance and clinical relevance on 11-point single-item scales, with a focus on immune fitness, i.e. the body’s capacity to mount an appropriate immune response to health challenges. Drawing on existing literature, including studies in pain and dietary interventions, it is proposed that a minimum difference of 1.5 points on the single-item immune fitness scale may represent a clinically relevant improvement. Nevertheless, the interpretation of changes on single-item scales depends on the concept being evaluated, its impact on daily life, and the absolute scores reported.