Vessel wall morphology is equivalent for different artery types and localizations of advanced human aneurysms

Research output: Contribution to journalResearch articleContributedpeer-review


  • Albert Busch - , University Hospital of Würzburg, Karolinska Institutet, Technical University of Munich (Author)
  • Caroline Grimm - , University Hospital of Würzburg (Author)
  • Elena Hartmann - , University Hospital of Würzburg (Author)
  • Valentina Paloschi - , Karolinska University Hospital (Author)
  • Ralph Kickuth - , University Hospital of Würzburg (Author)
  • Mariette Lengquist - , Karolinska Institutet (Author)
  • Christoph Otto - , University Hospital of Würzburg (Author)
  • Per Eriksson - , Karolinska University Hospital (Author)
  • Richard Kellersmann - , University Hospital of Würzburg (Author)
  • Udo Lorenz - , University Hospital of Würzburg (Author)
  • Lars Maegdefessel - , Karolinska Institutet (Author)


Aneurysm formation occurs most frequently as abdominal aortic aneurysm (AAA), but is also seen in other localizations like thoracic or peripheral aneurysm. While initial mechanisms for aneurysm induction remain elusive, observations from AAA samples show transmural inflammation with proteolytic imbalance and repair mechanisms triggered by the innate immune system. However, limited knowledge exists about aneurysm pathology, especially for others than AAA. We compared 42 AAA, 15 popliteal, 3 ascending aortic, five iliac, two femoral, two brachial, one visceral and two secondary aneurysms to non-aneurysmatic controls by histologic analysis, immunohistochemistry and cytokine expression. Muscular and elastic type arteries show a uniform way of aneurysm formation. All samples show similar morphology. The changes compared to controls are distinct and include matrix remodeling with smooth muscle cell phenotype switch and angiogenesis, adventitial lymphoid cell accumulation and M1 macrophage homing together with neutrophil inflammation. Inflammatory cytokines are up-regulated accordingly. Comparative analysis of different disease entities can identify characteristic pathomechanisms. The phenotype of human advanced aneurysm disease is observed for elastic and muscular type arteries, does not differ between disease localizations and might, thus, be a unique response of the vasculature to the still unknown trigger of aneurysm formation.


Original languageEnglish
Pages (from-to)425-433
Number of pages9
JournalHistochemistry and cell biology
Issue number4
Publication statusPublished - Oct 2017
Externally publishedYes

External IDs

Scopus 85018764059


Sustainable Development Goals


  • Aortic Aneurysm, Abdominal/metabolism, Arteries/metabolism, Cytokines/biosynthesis, Humans, Immunohistochemistry