Unilateral Choanal Atresia: Indications of Long-Term Olfactory Deficits and Volumetric Brain Changes Postsurgically

Research output: Contribution to journalResearch articleContributedpeer-review



BACKGROUND: Very few studies have investigated whether unilateral choanal atresia is associated with permanent olfactory deficits.

OBJECTIVE: This study aimed to evaluate the olfactory performance of patients with unilateral choanal atresia postsurgically.

METHODS: Three patients with unilateral atresia were examined in terms of olfactory performance with the Sniffin' Sticks test (odor identification, threshold, and discrimination), size of the olfactory bulb, and volumetric brain changes.

RESULTS: All patients demonstrated significantly lower olfactory performance in terms of odor threshold on the same side with the choanal atresia. Grey matter reductions were found ipsilaterally in the hippocampus.

CONCLUSIONS: This pilot study indicates that persistent olfactory deficits and volumetric brain changes are present in patients with unilateral choanal atresia.


Original languageEnglish
Pages (from-to)89-92
Number of pages4
Issue number2
Publication statusPublished - 1 Mar 2022

External IDs

PubMedCentral PMC9153361
Scopus 85120615190



  • Brain/diagnostic imaging, Choanal Atresia/complications, Humans, Olfaction Disorders/etiology, Pilot Projects, Smell