This paper examines how Ian McHarg’s nature-based planning approach can be applied to the reconstruction of the Kahramanmaraş region of Turkey following the earthquake disaster and how it can offer opportunities for creating resilient, sustainable cities. McHarg’s “Design with Nature” approach aims at urban planning and design in harmony with natural processes and ecosystems. The article offers suggestions on how this approach can be used in the reconstruction works in Kahramanmaraş and highlights important issues to be considered in this process. Through a bibliographic analysis of McHarg’s Design with Nature, the article examines his ideas that nature-based planning should follow planning based on detailed field information. It also presents planning strategies on how this approach can be successfully applied in similar situations in Turkey and other countries through the Antakya case study.