Underestimated Olfactory Domains in Huntington's Disease: Odor Discrimination and Threshold
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
Background: Olfaction has recently found clinical value in some neurodegenerative disorders' prediction, discrimination, and prognosis. However, data originating from standard tests on olfactory dysfunction in Huntington's Disease (HD) are limited to Odor Identification (OI) which is only one domain of olfactory perceptual space. Methods: Twenty-five patients and 25 age and gender-matched controls were evaluated by the Sniffin' Sticks test in three domains of Odor Threshold (OT), Odor Discrimination (OD), OI, and the sum score of them (TDI). Patients' motor function was assessed based on Unified Huntington's Disease Rating Scale. Results: Compared to controls, patients' scores of TDI and all olfactory domains were significantly lower. Besides, our patients' OT and OD impairments were more frequently impaired than OI impairment (86% and 81% versus 34%, respectively). Conclusions: Olfactory impairment is a common finding in HD patients not limited to OI but is more pronounced in OD and OT.
Details
Original language | English |
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Pages (from-to) | 315 - 320 |
Journal | Journal of Laryngology and Otology |
Volume | 138 |
Publication status | Published - 2023 |
Peer-reviewed | Yes |
External IDs
PubMed | 37470108 |
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Mendeley | 132cf24a-63f1-38dd-8a0e-ad830875464b |
ORCID | /0000-0001-9713-0183/work/150330697 |
Keywords
ASJC Scopus subject areas
Keywords
- Huntington's Disease, Neurodegenerative Diseases, Olfaction Disorders, Smell