The closure process for packaging is a key process. It ensures the protective function of packaging and assures the packaged goods a long life. In this context, efficient and reliable sealing processes are essential for the production of sustainable packages. In this paper, several characteristics of the ultrasonic sealing process will be discussed and accompanied by experimental results. The introduction provides an insight into the ultrasonic sealing process, its heating mechanisms and the process steps. A comparison is made with conduction sealing. Furthermore, basic principles of heating and energy dissipation are related to the influences of the sealing parameters on the seam strength. The experimental studies were carried out on typical packaging films, such as polyamide-polyethylene laminates. The seam strength in ultrasonic sealing is compared with that in conductive sealing. A lower seam strength was found for ultrasonic sealing in all the tested films. Furthermore, the sealing behaviour of the packaging films contaminated with different kinds of foods was analysed for both sealing methods. Although the ultrasonic sealing method has marginal advantages for bulk materials such as wheat flour, conduction sealing was shown to be better for other products. A comparison of the energy consumption during the ultrasonic and conduction sealing verified the advantages of ultrasonic sealing. In particular for thick packaging films, the amount of energy required for bonding is significantly lower than for conduction sealing. In summary, this paper provides a survey of the characteristics of the ultrasonic sealing method in packaging applications - its advantages and limitations.