Type I Interferon Signature in Chilblain-Like Lesions Associated with the COVID-19 Pandemic
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Contributors
Abstract
Contemporarily to the new SARS-CoV-2 mediated COVID-19 pandemic, a rise in patients with acral chilblain lesions has been described. They manifest late after mild disease or asymptomatic exposure to SARS-CoV-2. Their pathogenic evolution is currently unknown. In biopsies from three patients with acral partially ulcerating chilblain lesions that occurred associated to the COVID-19 pandemic, we analysed the expression of type I interferon induced proteins and signal transduction kinases. Histology demonstrated perivascular and periadnexal lymphohistiocytic infiltrates and endothelial dominated MxA-staining, as well as pJAK1 activation. Our findings demonstrate induction of the type I IFN pathway in lesional sections of COVID-19-associated chilblain-like lesions. This may indicate a local antiviral immune activation status associated with preceding exposure to SARS-CoV-2.
Details
Original language | English |
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Pages (from-to) | 57-63 |
Number of pages | 7 |
Journal | Dermatopathology : official journal of the European Society of Dermatopathology (ESDP) |
Volume | 7 |
Issue number | 3 |
Publication status | Published - 13 Oct 2020 |
Peer-reviewed | Yes |
External IDs
PubMedCentral | PMC7768511 |
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ORCID | /0000-0002-4330-1861/work/152544366 |