Two-phase clustering strategy for gene expression data sets

Research output: Contribution to book/Conference proceedings/Anthology/ReportConference contributionContributedpeer-review

Contributors

  • Dirk Habich - , Chair of Databases (Author)
  • Thomas Wächter - , TUD Dresden University of Technology (Author)
  • Wolfgang Lehner - , Chair of Databases (Author)
  • Christian Pilarsky - , Department of Visceral, Thoracic and Vascular Surgery (Author)

Abstract

In the context of genome research, the method of gene expression analysis has been used for several years. Related microarray experiments are conducted all over the world, and consequently, a vast amount of microarray data sets are produced. Having access to this variety of repositories, researchers would like to incorporate this data in their analyses to increase the statistical significance of their results. In this paper, we present a new two-phase clustering strategy which is based on the combination of local clustering results to obtain a global clustering. The advantage of such a technique is that each microarray data set can be normalized and clustered separately. The set of different relevant local clustering results is then used to calculate the global clustering result. Furthermore, we present an approach based on technical as well as biological quality measures to determine weighting factors for quantifying the local results proportion within the global result. The better the attested quality of the local results, the stronger their impact on the global result.

Details

Original languageEnglish
Title of host publicationSAC '06: Proceedings of the 2006 ACM symposium on Applied computing
Pages145-150
Number of pages6
Publication statusPublished - 2006
Peer-reviewedYes

Conference

Title2006 ACM Symposium on Applied Computing
Duration23 - 27 April 2006
CityDijon
CountryFrance

External IDs

ORCID /0000-0001-8107-2775/work/200630409

Keywords

Research priority areas of TU Dresden

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ASJC Scopus subject areas