Treatment of critical bone defects using calcium phosphate cement and mesoporous bioactive glass providing spatiotemporal drug delivery

Research output: Contribution to journalResearch articleContributedpeer-review



Calcium phosphate cements (CPC) are currently widely used bone replacement materials with excellent bioactivity, but have considerable disadvantages like slow degradation. For critical-sized defects, however, an improved degradation is essential to match the tissue regeneration, especially in younger patients who are still growing. We demonstrate that a combination of CPC with mesoporous bioactive glass (MBG) particles led to an enhanced degradation in vitro and in a critical alveolar cleft defect in rats. Additionally, to support new bone formation the MBG was functionalized with hypoxia conditioned medium (HCM) derived from rat bone marrow stromal cells. HCM-functionalized scaffolds showed an improved cell proliferation and the highest formation of new bone volume. This highly flexible material system together with the drug delivery capacity is adaptable to patient specific needs and has great potential for clinical translation.


Original languageEnglish
Pages (from-to)402-419
Number of pages18
JournalBioactive Materials
Publication statusPublished - Oct 2023

External IDs

Scopus 85161809174
Mendeley f2d17846-d258-3973-aefe-bea8a2ad9681
ORCID /0000-0002-3734-665X/work/142255880
ORCID /0000-0001-9075-5121/work/148605027
ORCID /0000-0001-9075-5121/work/150882728



  • 3D plotting, Alveolar cleft defect, Calcium phosphate cement, Drug delivery, Mesoporous bioactive glass