Transvenous lead extraction of implantable cardioverter-defibrillators: A comprehensive outcome-and risk factor analysis

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • GALLERY investigators - (Author)
  • Department for Cardiosurgery (at Herzzentrum Dresden)
  • Bethesda Johanniter Hospital Duisburg-Rheinhausen
  • Immanuel Albertinen Diakonie
  • University Hospital Hamburg Eppendorf
  • Heart Center Brandenburg Bernau
  • Asklepios Klinik St. Georg
  • Kerckhoff Clinic
  • Department of Cardiac Surgery
  • Marien-Hospital Siegen
  • Deutsches Zentrum für Herz-Kreislaufforschung (DZHK)
  • University Hospital Carl Gustav Carus Dresden

Abstract

BACKGROUND: Device complications, such as infection or lead dysfunction necessitating transvenous lead extraction (TLE) are continuously rising amongst patients with transvenous implantable-cardioverter-defibrillator (ICD).

OBJECTIVES: Aim of this study was to characterize the procedural outcome and risk-factors of patients with indwelling 1- and 2-chamber ICD undergoing TLE.

METHODS: We conducted a subgroup analysis of all ICD patients in the GALLERY (GermAn Laser Lead Extraction RegistrY) database. Predictors for procedural failure and all-cause mortality were assessed.

RESULTS: We identified 842 patients with an ICD undergoing TLE with the mean age of 62.8 ± 13.8 years. A total number of 1610 leads were treated with lead dysfunction (48.5%) as leading indication for extraction, followed by device-related infection (45.4%). Lead-per-patient ratio was 1.91 ± 0.88 and 60.0% of patients had dual-coil defibrillator leads. Additional extraction tools, such as mechanical rotating dilator sheaths and snares were utilized in 6.5% of cases. Overall procedural complications occurred in 4.3% with 2.0% major complications and a procedure-related mortality of 0.8%. Clinical success rate was 97.9%. All-cause in-hospital mortality was 3.4%, with sepsis being the leading cause for mortality. Multivariate analysis revealed lead-age ≥10 years (OR:5.82, 95%CI:2.1-16.6; p = .001) as independent predictor for procedural failure. Systemic infection (OR:9.57, 95%CI:2.2-42.4; p < .001) and procedural complications (OR:8.0, 95%CI:2.8-23.3; p < .001) were identified as risk factors for all-cause mortality.

CONCLUSIONS: TLE is safe and efficacious in patients with 1- and 2-chamber ICD. Although lead dysfunction is the leading indication for extraction, systemic device-related infection is the main driver of all-cause mortality for ICD patients undergoing TLE.

Details

Original languageEnglish
Pages (from-to)815-823
Number of pages9
JournalPACE - Pacing and Clinical Electrophysiology
Volume46
Issue number8
Publication statusPublished - Aug 2023
Peer-reviewedYes

External IDs

Scopus 85165302789

Keywords

Keywords

  • Humans, Middle Aged, Aged, Child, Defibrillators, Implantable/adverse effects, Risk Factors, Device Removal/adverse effects, Retrospective Studies, Treatment Outcome, Pacemaker, Artificial/adverse effects