TLR4 and IL-18 gene variants in chronic periodontitis: Impact on disease susceptibility and severity

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Abstract

The aim of the study was to assess whether genotypes in the Toll-like receptor 4 gene and in the promoter of the interleukin-18 gene are associated with the susceptibility to chronic periodontitis. 108 chronic periodontitis patients and 76 controls were genotyped for c.896A>G/1196C>T (TLR4 gene) and for c.-368G>C/ c.-838C>A (IL-18 promoter). There were no significant differences in genotype and allele distributions between the study groups. Periodontitis severity in patients with TLR4 c.896AG/1196CT genotype was significantly higher than wildtype carriers. The percentage of teeth with clinical attachment loss > or = 5 mm was 77.3% and 58.8%, respectively (p < or = 0.006, t-test). All subjects were further classified into carriers and non-carriers of at least one variant of each gene. A logistic regression analysis adjusted for gender, smoking, and age showed no association between gene variant carrier status and periodontitis (OR = 1.98, 95% CI 0.61-6.39). The results did not show that IL-18 and TLR4 variants have an effect on the susceptibility to chronic periodontitis. Considering the low number of periodontitis patients carrying TLR4 variants (11%), a comparison of the periodontitis severity depending on the genotype has to be interpreted cautiously.

Details

Original languageEnglish
Number of pages14
JournalImmunological Investigations : A Journal of Molecular and Cellular Immunology
Volume38
Issue number3-4
Publication statusPublished - 2009
Peer-reviewedYes

External IDs

researchoutputwizard legacy.publication#31754
Scopus 70350666314
ORCID /0000-0002-0228-6140/work/146167264
ORCID /0000-0002-0423-7107/work/147142730

Keywords