Tissue interplay during morphogenesis
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
The process by which biological systems such as cells, tissues and organisms acquire shape has been named as morphogenesis and it is central to a plethora of biological contexts including embryo development, wound healing, or even cancer. Morphogenesis relies in both self-organising properties of the system and in environmental inputs (biochemical and biophysical). The classical view of morphogenesis is based on the study of external biochemical molecules, such as morphogens. However, recent studies are establishing that the mechanical environment is also used by cells to communicate within tissues, suggesting that this mechanical crosstalk is essential to synchronise morphogenetic transitions and self-organisation. In this article we discuss how tissue interaction drive robust morphogenesis, starting from a classical biochemical view, to finalise with more recent advances on how the biophysical properties of a tissue feedback with their surroundings to allow form acquisition. We also comment on how in silico models aid to integrate and predict changes in cell and tissue behaviour. Finally, considering recent advances from the developmental biomechanics field showing that mechanical inputs work as cues that promote morphogenesis, we invite to revisit the concept of morphogen.
Details
Original language | English |
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Pages (from-to) | 12-23 |
Number of pages | 12 |
Journal | Seminars in Cell and Developmental Biology |
Volume | 147 |
Publication status | Published - 30 Sept 2023 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
PubMed | 37002130 |
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Keywords
Sustainable Development Goals
ASJC Scopus subject areas
Keywords
- Biochemical signals, Biomechanical signals, Tissue morphogenesis