Rationale and Objectives: To investigate the impact of operator experience and the overall expertise of the medical center on technical success and procedural parameters of transjugular intrahepatic portosystemic shunt (TIPS) in a longitudinal setting. Materials and Methods: TIPS procedures conducted at a German tertiary hospital from 2017 to 2023 were enrolled retrospectively. The impact of the center's expertise on technical success and procedural parameters was assessed by logistic and linear regressions stratified by year. Comparative analyses between more and less experienced operators were performed using Mann–Whitney U, Chi-square, and Fisher's exact tests. Results: A total of 245 TIPS procedures (161 men, mean age 59.8 ± 10.9 years) were performed, with a technical success rate of 95.5% (234/245). Technical success remained stable over time (2017: 91.7% vs. 2023: 94.0%, p = 0.532). Over time, significant reductions were observed in total procedure time (2017: 63.4 ± 22.1 min vs. 2023: 44.4 ± 29.1 min, p<0.001), fluoroscopy time (2017: 18.8 ± 10.6 min vs. 2023: 12.8 ± 8.6 min, p = 0.002), radiation dose (2017: 114.5 ± 113.7 Gy*cm² vs. 2023: 51.3 ± 33.3 Gy*cm²; p<0.001), and contrast agent usage (2017: 72.0 ± 34.6 mL vs. 2023: 48.1 ± 24.7 mL, p<0.001). More experienced operators had significantly shorter fluoroscopy times than less experienced operators (14.0 ± 9.9 min vs. 16.4 ± 9.1 min, p = 0.016). Conclusion: TIPS is a highly technically successful procedure. Increased experience at the performing center is associated with reduced procedure times, fluoroscopy times, and radiation doses, while technical success rates remain stable. Additionally, procedures performed by more experienced operators were associated with shorter fluoroscopy times.