Theory of Cargo and Membrane Trafficking

Research output: Contribution to book/conference proceedings/anthology/reportEntry for encyclopedia/dictionaryInvitedpeer-review

Contributors

Abstract

Endocytosis underlies many cellular functions including signaling and nutrient uptake. The endocytosed cargo gets redistributed across a dynamic network of endosomes undergoing fusion and fission. Here, a theoretical approach is reviewed which can explain how the microscopic properties of endosome interactions cause the emergent macroscopic properties of cargo trafficking in the endosomal network. The theory has been tested experimentally. Parameters of the microscopic processes and their dependencies on endosome properties have been quantified for specific experimental conditions. This theory could also be used to infer mechanisms of signal-trafficking crosstalk. It is applicable to in vivo systems since fixed samples at few time points suffice as input data.

Details

Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
PublisherElsevier
Pages225-231
Number of pages7
Volume6
Edition2
ISBN (electronic)978-0-12-821624-8
Publication statusPublished - 1 Jan 2022
Peer-reviewedYes

External IDs

ORCID /0000-0003-0137-5106/work/147674383

Keywords

Keywords

  • Endocytosis, Endosome, Fission, Fusion, Intracellular transport, Mathematical model, Membrane biophysics, Power law, Quantitative biology, Theory, Vesicle