The Treatment of Substance Use Disorders: Recent Developments and New Perspectives

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Annika Rosenthal - , Charité – Universitätsmedizin Berlin (Author)
  • Claudia Ebrahimi - , Chair of Addiction Research, Charité – Universitätsmedizin Berlin (Author)
  • Friederike Wedemeyer - , Charité – Universitätsmedizin Berlin (Author)
  • Nina Romanczuk-Seiferth - , Charité – Universitätsmedizin Berlin (Author)
  • Anne Beck - , Charité – Universitätsmedizin Berlin (Author)

Abstract

Substance-related disorders are complex psychiatric disorders that are characterized by continued consumption in spite of harmful consequences. Addiction affects various brain networks critically involved in learning, reward, and motivation, as well as inhibitory control. Currently applied therapeutic approaches aim at modification of behavior that ultimately leads to decrease of consumption or abstinence in individuals with substance use disorders. However, traditional treatment methods might benefit from recent neurobiological and cognitive neuroscientific research findings. Novel cognitive-behavioral approaches in the treatment of addictive behavior aim at enhancement of strategies to cope with stressful conditions as well as craving-inducing cues and target erroneous learning mechanisms, including cognitive bias modification, reconsolidation-based interventions, mindfulness-based interventions, virtual-reality-based cue exposure therapy as well as pharmacological augmentation strategies. This review discusses therapeutic strategies that target dysregulated neurocognitive processes associated with the development and maintenance of disordered substance use and may hold promise as effective treatments for substance-related disorders.

Details

Original languageEnglish
Pages (from-to)451-472
Number of pages22
JournalNeuropsychobiology
Volume81
Issue number5
Publication statusPublished - Dec 2022
Peer-reviewedYes

External IDs

Scopus 85133132099
unpaywall 10.1159/000525268
Mendeley a35971ca-f984-39fe-9cfb-cc92332490a4
WOS 000815780300001

Keywords

Keywords

  • Behavior, Addictive, Craving, Cues, Humans, Motivation, Substance-Related Disorders/therapy