The traceless Staudinger ligation with fluorine-18: A novel and versatile labeling technique for the synthesis of PET-radiotracers

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Marc Pretze - , Department of Nuclear Medicine, Helmholtz-Zentrum Dresden-Rossendorf (Author)
  • Frank Wuest - , University of Alberta (Author)
  • Tim Peppel - , University of Rostock (Author)
  • Martin Köckerling - , University of Rostock (Author)
  • Constantin Mamat - , Helmholtz-Zentrum Dresden-Rossendorf (Author)

Abstract

The development of rapid radiolabeling techniques under mild reaction conditions involving the short-lived positron emitter fluorine-18 remains a special challenge in organic PET chemistry. This work describes a novel and facile application of the traceless Staudinger ligation as a mild and versatile labeling method for preparation of various radiotracers labeled with fluorine-18.

Details

Original languageEnglish
Pages (from-to)6410-6414
Number of pages5
JournalTetrahedron letters
Volume51
Issue number49
Publication statusPublished - 8 Dec 2010
Peer-reviewedYes

External IDs

ORCID /0000-0002-6432-5694/work/151982355

Keywords

ASJC Scopus subject areas

Keywords

  • Bioorthogonal, Fluorine-18, Radiolabeling, Traceless Staudinger ligation