The Role of the Left Inferior Parietal Cortex in Gilles de la Tourette Syndrome—An rTMS Study

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Theresa Paulus - , University of Lübeck (Author)
  • Lynn Wernecke - , University of Lübeck (Author)
  • Annik Lundie - , University of Lübeck (Author)
  • Julia Friedrich - , University of Lübeck (Author)
  • Julius Verrel - , University of Lübeck (Author)
  • Tina Rawish - , University of Lübeck (Author)
  • Anne Weissbach - , University of Lübeck (Author)
  • Christian Frings - , Trier University (Author)
  • Christian Beste - , Department of Child and Adolescent Psychiatry and Psychotherapy, Department of Child and Adolescent Psychiatry and Psychotherapy, Shandong Normal University (Author)
  • Tobias Bäumer - , University of Lübeck (Author)
  • Alexander Münchau - , University of Lübeck (Author)

Abstract

Increased activity in the left inferior parietal cortex (BA40) plays a role in the generation of tics in the Gilles de la Tourette syndrome (GTS). Thus, inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to BA40 was hypothesized to alleviate symptoms in GTS. We investigated the immediate effects of single-session 1 Hz rTMS and sham stimulation delivered to the left BA40 on tics assessed with the Rush video protocol in 29 adults with GTS. There were no significant effects on tic symptoms following rTMS or sham stimulation. Moreover, there was no difference when comparing the effects of both stimulation conditions. Bayesian statistics indicated substantial evidence against an intervention effect. The left BA40 appears not to be a useful target for 1 Hz rTMS to modulate tic symptoms in GTS patients.

Details

Original languageEnglish
Article number980
JournalBiomedicines
Volume11
Issue number3
Publication statusPublished - 22 Mar 2023
Peer-reviewedYes

External IDs

ORCID /0000-0002-2989-9561/work/146788807

Keywords

ASJC Scopus subject areas

Keywords

  • BA40, Gilles de la Tourette syndrome, left inferior parietal cortex, repetitive transcranial magnetic stimulation, rush score, tics