The role of negative pressure wound therapy with instillation and dwell time in the treatment of deep sternal wound infections—A retrospective cohort study
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
BACKGROUND AND AIMS: Negative pressure wound therapy (NPWT) has gained a central role in the treatment of deep sternal wound infections (DSWIs) after median thoracotomy. Our study aims at proving the safety of using NPWT with instillation and dwell time (NPWTi-d) in the treatment of DSWI.
METHODS: We retrospectively evaluated the patients who were treated at our institution between March 2018 and November 2021 for DSWI after radical sternectomy using NPWT or NPWTi-d. The NPWTi-d was applied to start the first postoperative day using 75 mmHg negative pressure for 3 h, followed by instillation of sodium hypochlorite <0.08% with a 3-min dwell time.
RESULTS: The NPWTi-d group showed a shorter length of stay (29.39 ± 12.09 vs. 39.54 ± 17.07 days; p = 0.049), a shorter elapsed time between the debridement and the flap coverage (7.18 ± 4.27 vs. 11.86 ± 7.7 days; p = 0.003) and less operative or nonoperative dressing changes (1.73 ± 1.14 vs. 2.68 ± 56; p < 0.001). The in-hospital mortality was 8.2%, with no significant differences between the two groups (p = 1).
CONCLUSION: NPWTi-d can be safely employed in the treatment of DSWI. Further prospective randomized studies need to establish the role of NPWTi-d in the control of infection and biofilm as well as in wound healing.
Details
Original language | English |
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Article number | e1430 |
Journal | Health Science Reports |
Volume | 6 |
Issue number | 7 |
Publication status | Published - Jul 2023 |
Peer-reviewed | Yes |
External IDs
ORCID | /0000-0003-4633-2695/work/145698739 |
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PubMed | 37465238 |
PubMedCentral | PMC10350553 |
Keywords
ASJC Scopus subject areas
Keywords
- cardiac surgery, instillation, negative pressure wound therapy, surgical wound infection, wound healing