The role of integrins and coreceptors in refining thresholds for B-cell responses

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Facundo D. Batista - , Cancer Research UK (First author)
  • Eloisa Arana - , Cancer Research UK (Author)
  • Patricia Barral - , Cancer Research UK (Author)
  • Yolanda R. Carrasco - , Cancer Research UK (Author)
  • David Depoil - , Cancer Research UK (Author)
  • Julia Eckl-Dorna - , Cancer Research UK (Author)
  • Sebastian Fleire - , Cancer Research UK (Author)
  • Kathy Howe - , Cancer Research UK (Author)
  • Anne Vehlow - , Cancer Research UK (Author)
  • Michele Weber - , Cancer Research UK (Author)
  • Bebhinn Treanor - , Cancer Research UK (Last author)

Abstract

Despite compelling evidence that a large proportion of antigens encountered in vivo by B cells are membrane bound, the general view is that B cells are mainly activated by soluble antigens. This notion may have been biased somewhat over the years because the high affinity of the B-cell receptor (BCR) for soluble intact ligands allows efficient B-cell stimulation in vitro. In vivo, however, even soluble antigens are likely to be deposited on the surface of antigen-presenting cells, either by complement or Fc receptors in the form of immune complexes, thus becoming more potent stimulators of B-cell activation. In this framework, the BCR works in a complex environment of integrins and coreceptors, as well as the B-cell cytoskeleton. Over the last few years, we have focused on B-cell membrane-bound antigen recognition. Here, we discuss some of our findings in the context of what is currently known in this exciting new field.

Details

Original languageEnglish
Pages (from-to)197-213
JournalImmunological Reviews
Volume2007
Issue number218
Publication statusPublished - Aug 2007
Peer-reviewedYes
Externally publishedYes

External IDs

ORCID /0000-0002-5381-0547/work/146642820
Scopus 34447340492

Keywords

Research priority areas of TU Dresden

ASJC Scopus subject areas