The role of integrins and coreceptors in refining thresholds for B-cell responses
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Despite compelling evidence that a large proportion of antigens encountered in vivo by B cells are membrane bound, the general view is that B cells are mainly activated by soluble antigens. This notion may have been biased somewhat over the years because the high affinity of the B-cell receptor (BCR) for soluble intact ligands allows efficient B-cell stimulation in vitro. In vivo, however, even soluble antigens are likely to be deposited on the surface of antigen-presenting cells, either by complement or Fc receptors in the form of immune complexes, thus becoming more potent stimulators of B-cell activation. In this framework, the BCR works in a complex environment of integrins and coreceptors, as well as the B-cell cytoskeleton. Over the last few years, we have focused on B-cell membrane-bound antigen recognition. Here, we discuss some of our findings in the context of what is currently known in this exciting new field.
Details
Original language | English |
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Pages (from-to) | 197-213 |
Journal | Immunological Reviews |
Volume | 2007 |
Issue number | 218 |
Publication status | Published - Aug 2007 |
Peer-reviewed | Yes |
Externally published | Yes |
External IDs
ORCID | /0000-0002-5381-0547/work/146642820 |
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Scopus | 34447340492 |