The ReCoDe addiction research consortium: Losing and regaining control over drug intake-Findings and future perspectives

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Rainer Spanagel - , German Center for Mental Health (DZPG) (Author)
  • Patrick Bach - , German Center for Mental Health (DZPG) (Author)
  • Tobias Banaschewski - , Universitätsmedizin Mannheim (Author)
  • Anne Beck - , University of Potsdam (Author)
  • Felix Bermpohl - , Charité – Universitätsmedizin Berlin (Author)
  • Rick E Bernardi - , Universitätsmedizin Mannheim (Author)
  • Christian Beste - , Department of Child and Adolescent Psychiatry and Psychotherapy (Author)
  • Lorenz Deserno - , University Hospital of Würzburg (Author)
  • Daniel Durstewitz - , German Center for Mental Health (DZPG) (Author)
  • Ulrich Ebner-Priemer - , German Center for Mental Health (DZPG) (Author)
  • Tanja Endrass - , Chair of Addiction Research (Author)
  • Karen D Ersche - , University of Cambridge (Author)
  • Gordon Feld - , Heidelberg University  (Author)
  • Martin Fungisai Gerchen - , Heidelberg University  (Author)
  • Björn Gerlach - , Universitätsmedizin Mannheim (Author)
  • Thomas Goschke - , Chair of General Psychology (Author)
  • Anita Christiane Hansson - , Universitätsmedizin Mannheim (Author)
  • Christine Heim - , Charité – Universitätsmedizin Berlin (Author)
  • Stefan Kiebel - , Chair of cognitive computational neuroscience (Author)
  • Falk Kiefer - , German Center for Mental Health (DZPG) (Author)
  • Peter Kirsch - , Heidelberg University  (Author)
  • Clemens Kirschbaum - , Universitätsmedizin Mannheim (Author)
  • Georgia Koppe - , Universitätsmedizin Mannheim (Author)
  • Bernd Lenz - , German Center for Mental Health (DZPG) (Author)
  • Shuyan Liu - , Charité – Universitätsmedizin Berlin (Author)
  • Michael Marxen - , Department of Psychiatry and Psychotherapy (Author)
  • Marcus W Meinhardt - , Universitätsmedizin Mannheim (Author)
  • Andreas Meyer-Lindenberg - , German Center for Mental Health (DZPG) (Author)
  • Christiane Montag - , Charité – Universitätsmedizin Berlin (Author)
  • Christian P Müller - , Universitätsmedizin Mannheim, University Hospital at the Friedrich-Alexander University Erlangen-Nürnberg (Author)
  • Wolfgang E Nagel - , Center for Information Services and High Performance Computing (ZIH) (Author)
  • Ana M M Oliveria - , Universitätsmedizin Mannheim (Author)
  • David Owald - , Charité – Universitätsmedizin Berlin (Author)
  • Maximilian Pilhatsch - , Department of Psychiatry and Psychotherapy (Author)
  • Josef Priller - , German Center for Mental Health (DZPG) (Author)
  • Michael A Rapp - , German Center for Mental Health (DZPG) (Author)
  • Markus Reichert - , Universitätsmedizin Mannheim, Ruhr University Bochum (Author)
  • Stephan Ripke - , Charité – Universitätsmedizin Berlin (Author)
  • Kerstin Ritter - , Charité – Universitätsmedizin Berlin (Author)
  • Nina Romanczuk-Seiferth - , MSB Medical School Berlin Hochschule für Gesundheit und Medizin (Author)
  • Florian Schlagenhauf - , Charité – Universitätsmedizin Berlin (Author)
  • Emanuel Schwarz - , German Center for Mental Health (DZPG) (Author)
  • Sarah Schwöbel - , Universitätsmedizin Mannheim (Author)
  • Michael N Smolka - , Department of Psychiatry and Psychotherapy (Author)
  • Surjo R Soekadar - , Charité – Universitätsmedizin Berlin (Author)
  • Wolfgang H Sommer - , German Center for Mental Health (DZPG) (Author)
  • Ann-Kathrin Stock - , Universitätsmedizin Mannheim (Author)
  • Andreas Ströhle - , Charité – Universitätsmedizin Berlin (Author)
  • Heike Tost - , German Center for Mental Health (DZPG) (Author)
  • Sabine Vollstädt-Klein - , Universitätsmedizin Mannheim (Author)

Abstract

Substance use disorders (SUDs) are seen as a continuum ranging from goal-directed and hedonic drug use to loss of control over drug intake with aversive consequences for mental and physical health and social functioning. The main goals of our interdisciplinary German collaborative research centre on Losing and Regaining Control over Drug Intake (ReCoDe) are (i) to study triggers (drug cues, stressors, drug priming) and modifying factors (age, gender, physical activity, cognitive functions, childhood adversity, social factors, such as loneliness and social contact/interaction) that longitudinally modulate the trajectories of losing and regaining control over drug consumption under real-life conditions. (ii) To study underlying behavioural, cognitive and neurobiological mechanisms of disease trajectories and drug-related behaviours and (iii) to provide non-invasive mechanism-based interventions. These goals are achieved by: (A) using innovative mHealth (mobile health) tools to longitudinally monitor the effects of triggers and modifying factors on drug consumption patterns in real life in a cohort of 900 patients with alcohol use disorder. This approach will be complemented by animal models of addiction with 24/7 automated behavioural monitoring across an entire disease trajectory; i.e. from a naïve state to a drug-taking state to an addiction or resilience-like state. (B) The identification and, if applicable, computational modelling of key molecular, neurobiological and psychological mechanisms (e.g., reduced cognitive flexibility) mediating the effects of such triggers and modifying factors on disease trajectories. (C) Developing and testing non-invasive interventions (e.g., Just-In-Time-Adaptive-Interventions (JITAIs), various non-invasive brain stimulations (NIBS), individualized physical activity) that specifically target the underlying mechanisms for regaining control over drug intake. Here, we will report on the most important results of the first funding period and outline our future research strategy.

Details

Original languageEnglish
Article numbere13419
Pages (from-to)e13419
JournalAddiction biology
Volume29
Issue number7
Publication statusPublished - Jul 2024
Peer-reviewedYes

External IDs

PubMedCentral PMC11215792
Scopus 85197276995
ORCID /0000-0002-8845-8803/work/163762715
ORCID /0000-0002-2989-9561/work/163765541
ORCID /0000-0001-5398-5569/work/163765825
ORCID /0000-0001-8870-0041/work/163766356

Keywords

Keywords

  • Alcoholism, Animals, Behavior, Addictive, Germany, Humans, Substance-Related Disorders