The nature and identification of quantitative trait loci: A community's view

Research output: Contribution to journal › Review article › Contributed › peer-review

Contributors

  • Oduola Abiola - , King's College London (KCL) (Author)
  • Joe M. Angel - , University of Texas at Austin (Author)
  • Philip Avner - , Institut Pasteur Paris (Author)
  • Alexander A. Bachmanov - , Monell Chemical Senses Center (Author)
  • John K. Belknap - , Oregon Health and Science University (Author)
  • Beth Bennett - , University of Colorado Boulder (Author)
  • Elizabeth P. Blankenhorn - , Drexel University (Author)
  • David A. Blizard - , Pennsylvania State University (Author)
  • Valerie Bolivar - , Wadsworth Center for Laboratories and Research (Author)
  • Gudrun A. Brockmann - , Research Institute for Farm Animal Biology (FBN) (Author)
  • Kari J. Buck - , Oregon Health and Science University (Author)
  • Jean Francois Bureau - , Institut Pasteur Paris (Author)
  • William L. Casley - , Health Canada (Author)
  • Elissa J. Chesler - , University of Tennessee Health Science Center (Author)
  • James M. Cheverud - , Washington University St. Louis (Author)
  • Gary A. Churchill - , Jackson Laboratory (Author)
  • Melloni Cook - , University of Memphis (Author)
  • John C. Crabbe - , Oregon Health and Science University (Author)
  • Wim E. Crusio - , University of Massachusetts Medical School (Author)
  • Ariel Darvasi - , Hebrew University of Jerusalem (Author)
  • Gerald de Haan - , University of Groningen (Author)
  • Peter Demant - , Roswell Park Cancer Institute (Author)
  • R. W. Doerge - , Purdue University (Author)
  • Rosemary W. Elliott - , Roswell Park Cancer Institute (Author)
  • Charles R. Farber - , University of California at Davis (Author)
  • Lorraine Flaherty - , Wadsworth Center for Laboratories and Research (Author)
  • Jonathan Flint - , University of Oxford (Author)
  • Howard Gershenfeld - , University of Texas Southwestern Medical Center (Author)
  • John P. Gibson - , International Livestock Research Institute (Author)
  • Jing Gu - , University of Tennessee Health Science Center (Author)
  • Weikuan Gu - , University of Tennessee Health Science Center (Author)
  • Heinz Himmelbauer - , Max Planck Institute for Molecular Genetics (Author)
  • Robert Hitzemann - , Oregon Health and Science University (Author)
  • Hui Chen Hsu - , University of Alabama at Birmingham (Author)
  • Kent Hunter - , National Cancer Institute (NCI) (Author)
  • Fuad A. Iraqi - , International Livestock Research Institute (Author)
  • Ritsert C. Jansen - , University of Groningen (Author)
  • Thomas E. Johnson - , University of Colorado Boulder (Author)
  • Byron C. Jones - , Pennsylvania State University (Author)
  • Gerd Kempermann - , Center for Regenerative Therapies Dresden, German Center for Neurodegenerative Diseases, Dresden site (Partner: DZNE of the Helmholtz Association), Charité – Universitätsmedizin Berlin (Author)
  • Frank Lammert - , RWTH Aachen University (Author)
  • Lu Lu - , University of Tennessee Health Science Center (Author)
  • Kenneth F. Manly - , Roswell Park Cancer Institute (Author)
  • Douglas B. Matthews - , University of Memphis (Author)
  • Juan F. Medrano - , University of California at Davis (Author)
  • Margarete Mehrabian - , University of California at Los Angeles (Author)
  • Guy Mittleman - , University of Memphis (Author)
  • Beverly A. Mock - , National Cancer Institute (NCI) (Author)
  • Jeffrey S. Mogil - , McGill University (Author)
  • Xavier Montagutelli - , Institut Pasteur Paris (Author)

Abstract

This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

Details

Original languageEnglish
Pages (from-to)911-916
Number of pages6
JournalNature Reviews Genetics
Volume4
Issue number11
Publication statusPublished - Nov 2003
Peer-reviewedYes

External IDs

PubMed 14634638
ORCID /0000-0002-5304-4061/work/152544197

Keywords

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Library keywords