The many functions of SMC proteins in chromosome dynamics
Research output: Contribution to journal › Review article › Contributed › peer-review
Contributors
Abstract
Members of the structural maintenance of chromosomes (SMC) family share a characteristic design and configuration of protein domains that provides the molecular basis for the various functions of this family in chromosome dynamics. SMC proteins have a role in chromosome condensation, sister-chromatid cohesion, DNA repair and recombination, and gene dosage compensation, and they function in somatic and meiotic cells. As more is learned about how their unique design affects their function, a picture of a dynamic and varied protein family is emerging.
Details
Original language | English |
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Pages (from-to) | 767-78 |
Number of pages | 12 |
Journal | NATURE REVIEWS MOLECULAR CELL BIOLOGY |
Volume | 3 |
Issue number | 10 |
Publication status | Published - Oct 2002 |
Peer-reviewed | Yes |
External IDs
Scopus | 0036792404 |
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Keywords
Keywords
- Adenosine Triphosphatases/physiology, Animals, Cell Cycle Proteins/chemistry, Chromosomal Proteins, Non-Histone, Chromosomes/physiology, DNA Repair, DNA-Binding Proteins/physiology, Dosage Compensation, Genetic, Fungal Proteins, Macromolecular Substances, Meiosis, Models, Biological, Multiprotein Complexes, Nuclear Proteins/physiology, Protein Structure, Tertiary, Recombination, Genetic