The Image Biomarker Standardization Initiative: Standardized Convolutional Filters for Reproducible Radiomics and Enhanced Clinical Insights

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Philip Whybra - , Cardiff University (Author)
  • Alex Zwanenburg - , National Center for Tumor Diseases (NCT) Dresden, German Cancer Research Center (DKFZ), OncoRay - National Centre for Radiation Research in Oncology (Author)
  • Vincent Andrearczyk - , University of Applied Sciences and Arts of Western Switzerland (Author)
  • Roger Schaer - , University of Applied Sciences and Arts of Western Switzerland (Author)
  • Aditya P. Apte - , Memorial Sloan-Kettering Cancer Center (Author)
  • Alexandre Ayotte - , Université de Sherbrooke (Author)
  • Bhakti Baheti - , University of Pennsylvania, Indiana University-Purdue University Indianapolis (Author)
  • Spyridon Bakas - , University of Pennsylvania, Indiana University-Purdue University Indianapolis (Author)
  • Andrea Bettinelli - , IRCCS Istituto Oncologico Veneto - Padova (Author)
  • Ronald Boellaard - , Amsterdam University Medical Centers (UMC) (Author)
  • Luca Boldrini - , IRCCS Istituto Oncologico Veneto - Padova, Amsterdam University Medical Centers (UMC), A. Gemelli University Hospital Foundation IRCCS (Author)
  • Irène Buvat - , Université PSL (Author)
  • Gary J.R. Cook - , King's College London (KCL) (Author)
  • Florian Dietsche - , University of Zurich (Author)
  • Nicola Dinapoli - , IRCCS Istituto Oncologico Veneto - Padova, Amsterdam University Medical Centers (UMC) (Author)
  • Hubert S. Gabryś - , University of Zurich (Author)
  • Vicky Goh - , King's College London (KCL), Guy's and St Thomas' NHS Foundation Trust (Author)
  • Matthias Guckenberger - , University of Zurich (Author)
  • Mathieu Hatt - , Université de Bretagne Occidentale (Author)
  • Mahdi Hosseinzadeh - , TECVICO Corp., Tarbiat Modares University (Author)
  • Aditi Iyer - , Memorial Sloan-Kettering Cancer Center (Author)
  • Jacopo Lenkowicz - , IRCCS Istituto Oncologico Veneto - Padova, Amsterdam University Medical Centers (UMC) (Author)
  • Mahdi A.L. Loutfi - , Université de Sherbrooke (Author)
  • Steffen Löck - , OncoRay - National Center for Radiation Research in Oncology, University Hospital Carl Gustav Carus Dresden (Author)
  • Francesca Marturano - , IRCCS Istituto Oncologico Veneto - Padova (Author)
  • Olivier Morin - , University of California at San Francisco (Author)
  • Christophe Nioche - , A. Gemelli University Hospital Foundation IRCCS, Université PSL (Author)
  • Fanny Orlhac - , A. Gemelli University Hospital Foundation IRCCS, Université PSL, King's College London (KCL) (Author)
  • Sarthak Pati - , University of Pennsylvania, Indiana University-Purdue University Indianapolis (Author)
  • Arman Rahmim - , University of British Columbia (Author)
  • Seyed Masoud Rezaeijo - , Ahvaz Jundishapur University of Medical Sciences (Author)
  • Christopher G. Rookyard - , Cancer Research UK (Author)
  • Mohammad R. Salmanpour - , TECVICO Corp., University of British Columbia (Author)
  • Andreas Schindele - , University Hospital Augsburg (Author)
  • Isaac Shiri - , Geneva University Hospitals, University of Bern (Author)
  • Emiliano Spezi - , Cardiff University (Author)
  • Stephanie Tanadini-Lang - , University of Zurich (Author)
  • Florent Tixier - , Université de Bretagne Occidentale (Author)
  • Taman Upadhaya - , University of California at San Francisco (Author)
  • Vincenzo Valentini - , A. Gemelli University Hospital Foundation IRCCS, Catholic University of the Sacred Heart (Author)
  • Joost J.M. van Griethuysen - , Netherlands Cancer Institute, Utrecht University (Author)
  • Fereshteh Yousefirizi - , University of British Columbia (Author)
  • Habib Zaidi - , Geneva University Hospitals (Author)
  • Henning Müller - , University of Applied Sciences and Arts of Western Switzerland (Author)
  • Martin Vallières - , Université de Sherbrooke (Author)
  • Adrien Depeursinge - , University of Applied Sciences and Arts of Western Switzerland, University of Lausanne (Author)

Abstract

Filters are commonly used to enhance specific structures and patterns in images, such as vessels or peritumoral regions, to enable clinical insights beyond the visible image using radiomics. However, their lack of standardization restricts reproducibility and clinical translation of radiomics decision support tools. In this special report, teams of researchers who developed radiomics software participated in a three-phase study (September 2020 to December 2022) to establish a standardized set of filters. The first two phases focused on finding reference filtered images and reference feature values for commonly used convolutional filters: mean, Laplacian of Gaussian, Laws and Gabor kernels, separable and nonseparable wavelets (including decomposed forms), and Riesz transformations. In the first phase, 15 teams used digital phantoms to establish 33 reference filtered images of 36 filter configurations. In phase 2, 11 teams used a chest CT image to derive reference values for 323 of 396 features computed from filtered images using 22 filter and image processing configurations. Reference filtered images and feature values for Riesz transformations were not established. Reproducibility of standardized convolutional filters was validated on a public data set of multimodal imaging (CT, fluorodeoxyglucose PET, and T1-weighted MRI) in 51 patients with soft-tissue sarcoma. At validation, reproducibility of 486 features computed from filtered images using nine configurations × three imaging modalities was assessed using the lower bounds of 95% CIs of intraclass correlation coefficients. Out of 486 features, 458 were found to be reproducible across nine teams with lower bounds of 95% CIs of intraclass correlation coefficients greater than 0.75. In conclusion, eight filter types were standardized with reference filtered images and reference feature values for verifying and calibrating radiomics software packages. A web-based tool is available for compliance checking.

Details

Original languageEnglish
Article number231319
JournalRadiology
Volume310
Issue number2
Publication statusPublished - Feb 2024
Peer-reviewedYes

External IDs

ORCID /0000-0002-7017-3738/work/153110462
Scopus 85186751738

Keywords

Keywords

  • Humans, Radiomics, Reproducibility of Results, Biomarkers, Image Processing, Computer-Assisted, Multimodal Imaging