'Ain Ghazal is among the earliest large population centers known in the Middle East. A total of four major stratigraphic cultural units have been identified: 1) The oldest Middle Pre-Pottery Neolithic B (MPPNB) unit (10.2 to 9.5. cal ka BP) clearly corresponds with the early Holocene maximum Dead Sea levels. 2) The second unit consists of Late Pre-Pottery Neolithic B (LPPNB) in situ walls and hearths. 3) In the subsequent PPNC (8.9 to 8.6. cal ka BP) the population density at the settlement drops dramatically, which corresponds with a significant drop in the Dead Sea level. 4) The 4th stratigraphic unit is characterized by the "Yarmoukian rubble layer". Additionally, there is evidence for a previously unrecognized use of the site by Chalcolithic pastoralists. Sedimentological analyses reveal a constant increase in dust from a remote source during the entire human occupation period, which correlates well with the detectable drops in climatic humidity from the Dead Sea. As the major focus of this study, we can now rule out previous notions that the "Yarmoukian" rubble layer could have been produced by (catastrophic) slope-scale gravitational movements. To this point, it appears that the Neolithic mega-site was abandoned due to a climatic aridification.