The comorbidity and co-medication profile of patients with progressive supranuclear palsy

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Stephan Greten - , Hannover Medical School (MHH) (Author)
  • Florian Wegner - , Hannover Medical School (MHH) (Author)
  • Ida Jensen - , Hannover Medical School (MHH) (Author)
  • Lea Krey - , Hannover Medical School (MHH) (Author)
  • Sophia Rogozinski - , Hannover Medical School (MHH) (Author)
  • Meret Fehring - , Hannover Medical School (MHH) (Author)
  • Johanne Heine - , Hannover Medical School (MHH) (Author)
  • Johanna Doll-Lee - , Hannover Medical School (MHH) (Author)
  • Monika Pötter-Nerger - , University Hospital Hamburg Eppendorf (Author)
  • Molly Zeitzschel - , University Hospital Hamburg Eppendorf (Author)
  • Keno Hagena - , University Hospital Hamburg Eppendorf (Author)
  • David J Pedrosa - , University Hospital Gießen and Marburg (Author)
  • Carsten Eggers - , Department of Neurology (Author)
  • Katrin Bürk - , Kliniken Schmieder Gerlingen (Author)
  • Claudia Trenkwalder - , Paracelsus-Elena-Klinik Kassel (Author)
  • Inga Claus - , University Hospital Münster (Author)
  • Tobias Warnecke - , Klinikum Osnabrueck-Academic Teaching Hospital of the WWU Muenster (Author)
  • Patrick Süß - , University Hospital at the Friedrich-Alexander University Erlangen-Nürnberg (Author)
  • Jürgen Winkler - , University Hospital at the Friedrich-Alexander University Erlangen-Nürnberg (Author)
  • Doreen Gruber - , Movement Disorders Hospital (Author)
  • Florin Gandor - , Movement Disorders Hospital (Author)
  • Daniela Berg - , Kiel University (Author)
  • Steffen Paschen - , Kiel University (Author)
  • Joseph Classen - , University Hospital Leipzig (Author)
  • Elmar H Pinkhardt - , Ulm University (Author)
  • Jan Kassubek - , Ulm University (Author)
  • Wolfgang H Jost - , Parkinson-Klinik Ortenau (Author)
  • Lars Tönges - , Ruhr University Bochum (Author)
  • Andrea A Kühn - , Charité – Universitätsmedizin Berlin (Author)
  • Johannes Schwarz - , Department of Neurology (Author)
  • Oliver Peters - , German Center for Neurodegenerative Diseases (DZNE), Charité – Universitätsmedizin Berlin (Author)
  • Eman Dashti - , Department of Neurology (Author)
  • Josef Priller - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Eike J Spruth - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Patricia Krause - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Annika Spottke - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Anja Schneider - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Aline Beyle - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Okka Kimmich - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Markus Donix - , German Center for Neurodegenerative Diseases, Dresden site (Partner: DZNE of the Helmholtz Association), Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus Dresden (Author)
  • Robert Haussmann - , Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus Dresden (Author)
  • Moritz Brandt - , German Center for Neurodegenerative Diseases, Dresden site (Partner: DZNE of the Helmholtz Association), Department of Neurology, University Hospital Carl Gustav Carus Dresden (Author)
  • Elisabeth Dinter - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Jens Wiltfang - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Björn H Schott - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Inga Zerr - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Mathias Bähr - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Katharina Buerger - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Daniel Janowitz - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Robert Perneczky - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Boris-Stephan Rauchmann - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Endy Weidinger - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Johannes Levin - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Sabrina Katzdobler - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Emrah Düzel - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Wenzel Glanz - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Stefan Teipel - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Ingo Kilimann - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Johannes Prudlo - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Thomas Gasser - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Kathrin Brockmann - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Daniel C Hoffmann - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Thomas Klockgether - , German Center for Neurodegenerative Diseases (DZNE) (Author)
  • Olaf Krause - , Hannover Medical School (MHH) (Author)
  • Johannes Heck - , University of Bonn (Author)
  • Günter U Höglinger - , Hannover Medical School (MHH) (Author)
  • Martin Klietz - , Hannover Medical School (MHH) (Author)

Abstract

BACKGROUND: Progressive supranuclear palsy (PSP) is usually diagnosed in elderly. Currently, little is known about comorbidities and the co-medication in these patients.

OBJECTIVES: To explore the pattern of comorbidities and co-medication in PSP patients according to the known different phenotypes and in comparison with patients without neurodegenerative disease.

METHODS: Cross-sectional data of PSP and patients without neurodegenerative diseases (non-ND) were collected from three German multicenter observational studies (DescribePSP, ProPSP and DANCER). The prevalence of comorbidities according to WHO ICD-10 classification and the prevalence of drugs administered according to WHO ATC system were analyzed. Potential drug-drug interactions were evaluated using AiDKlinik®.

RESULTS: In total, 335 PSP and 275 non-ND patients were included in this analysis. The prevalence of diseases of the circulatory and the nervous system was higher in PSP at first level of ICD-10. Dorsopathies, diabetes mellitus, other nutritional deficiencies and polyneuropathies were more frequent in PSP at second level of ICD-10. In particular, the summed prevalence of cardiovascular and cerebrovascular diseases was higher in PSP patients. More drugs were administered in the PSP group leading to a greater percentage of patients with polypharmacy. Accordingly, the prevalence of potential drug-drug interactions was higher in PSP patients, especially severe and moderate interactions.

CONCLUSIONS: PSP patients possess a characteristic profile of comorbidities, particularly diabetes and cardiovascular diseases. The eminent burden of comorbidities and resulting polypharmacy should be carefully considered when treating PSP patients.

Details

Original languageEnglish
Pages (from-to)782-793
Number of pages12
JournalJournal of Neurology
Volume271 (2024)
Issue number2
Early online date6 Oct 2023
Publication statusPublished - 6 Oct 2023
Peer-reviewedYes

External IDs

ORCID /0000-0002-2936-5180/work/147674485
Scopus 85173912975
PubMed 37803149
Mendeley 9fd46021-4a14-3d99-aaa7-fa0af8d52b0b

Keywords

Sustainable Development Goals

Keywords

  • Polypharmacy, Comorbidities, Progressive supranuclear palsy, Drug–drug interactions

Library keywords