The Cellular and Molecular Basis of Translational Immunometabolism

Research output: Contribution to journalReview articleContributedpeer-review


  • Giuseppe Danilo Norata - , University of Milan, Bassini Hospital (Author)
  • Giuseppina Caligiuri - , Université Paris Cité, Universite Paris 7 (Author)
  • Triantafyllos Chavakis - , Institute of Clinical Chemistry and Laboratory Medicine (Author)
  • Giuseppe Matarese - , University of Salerno, IRCCS Multimedica - Milano (Author)
  • Mihai Gheorge Netea - , Radboud University Nijmegen (Author)
  • Antonino Nicoletti - , Universite Paris 7 (Author)
  • Luke A.J. O'Neill - , Trinity College Dublin (Author)
  • Federica M. Marelli-Berg - , Queen Mary University of London (Author)


The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive target area for therapeutic purposes. A neglected aspect in the translation of immunometabolism is the critical connection between systemic and cellular metabolism. Here, we discuss the importance of understanding and manipulating the integration of systemic and immune cell metabolism through in-depth analysis of immune cell phenotype and function in human metabolic diseases and, in parallel, of the effects of conventional metabolic drugs on immune cell differentiation and function. We examine how the recent identification of selective metabolic programs operating in distinct immune cell subsets and functions has the potential to deliver tools for cell- and function-specific immunometabolic targeting.


Original languageEnglish
Article number3167
Pages (from-to)421-434
Number of pages14
Issue number3
Publication statusPublished - 15 Sept 2015

External IDs

researchoutputwizard legacy.publication#66887
Scopus 84941637376
PubMed 26377896