The barriers to uptake of artificial intelligence in hepatology and how to overcome them

Research output: Contribution to journalReview articleContributedpeer-review

Contributors

  • Jan Clusmann - , Else Kröner Fresenius Center for Digital Health, University Hospital Aachen (Author)
  • Maria Balaguer-Montero - , Vall d'Hebron Institute of Oncology (VHIO) (Author)
  • Octavi Bassegoda - , Hospital Clinic of Barcelona (Author)
  • Carolin V Schneider - , Else Kröner-Fresenius Center for Digital Health (EKFZ), University Hospital Aachen (Author)
  • Tobias Seraphin - , University Hospital Duesseldorf (Author)
  • Ellis Paintsil - , King's College London (KCL) (Author)
  • Tom Luedde - , University Hospital Duesseldorf (Author)
  • Raquel Perez Lopez - , Vall d'Hebron Institute of Oncology (VHIO) (Author)
  • Julien Calderaro - , Université Paris-Est Créteil, Hôpital Henri Mondor, INSERM - Institut national de la santé et de la recherche médicale, European Reference Network on Rare Hepatological Diseases (Author)
  • Stephen Gilbert - , Else Kröner Fresenius Center for Digital Health (Author)
  • Thomas Marjot - , University of Oxford (Author)
  • Ashley Spann - , Vanderbilt University Medical Center (Author)
  • Debbie L Shawcross - , King's College London (KCL) (Author)
  • Sabela Lens - , Hospital Clinic of Barcelona, Instituto de Salud Carlos III (Author)
  • Eric Trépo - , University Hospital Brussels, Université libre de Bruxelles (ULB) (Author)
  • Jakob Nikolas Kather - , Department of Internal Medicine I, Else Kröner Fresenius Center for Digital Health, National Center for Tumor Diseases (NCT) Heidelberg (Author)

Abstract

Artificial intelligence (AI) methods in hepatology have proliferated since the mid-2010s, with numerous publications and some regulatory approvals. Yet, adoption of AI methods in real-world clinical practice and clinical research remains limited. Despite clear benefits of using AI to analyse complex data types in hepatology, such as histopathology, radiology images, multi-omics and more recently, natural language patient data, there are still substantial barriers and challenges to its integration into routine clinical workflows. In this position paper, we assess limitations and propose a set of clear recommendations aimed at both the development of AI systems and the broader hepatology environment to facilitate the transition of AI-based diagnostic, prognostic, and predictive tools into clinical care. In particular, we argue that the use of AI in clinical trials, seamless integration into hospital information systems and building AI literacy among clinicians will ultimately drive clinical adoption. We validate this perspective through a Delphi consensus involving 34 international experts from hepatology, AI, and data science, ensuring a comprehensive and consensus-driven evaluation of our recommendations.

Details

Original languageEnglish
Pages (from-to)1410-1426
Number of pages17
JournalJournal of hepatology
Volume83
Issue number6
Publication statusE-pub ahead of print - 18 Jul 2025
Peer-reviewedYes

External IDs

unpaywall 10.1016/j.jhep.2025.07.003
ORCID /0000-0002-1997-1689/work/196056486
Scopus 105022100216
ORCID /0000-0002-3730-5348/work/198594716

Keywords

Keywords

  • Artificial Intelligence/trends, Gastroenterology/methods, Humans, Liver Diseases/diagnosis