The Astrocyte: Metabolic Hub of the Brain

Research output: Contribution to book/Conference proceedings/Anthology/ReportChapter in book/Anthology/ReportInvitedpeer-review

Contributors

  • L. Felipe Barros - , Center for Scientific Studies (CECS), Universidad San Sebastián (Author)
  • Stefanie Schirmeier - , Chair of Zoology and Animal Physiology (Author)
  • Bruno Weber - , University of Zurich (Author)

Abstract

Astrocytic metabolism has taken center stage. Interposed between the neuron and the vasculature, astrocytes exert control over the fluxes of energy and building blocks required for neuronal activity and plasticity. They are also key to local detoxification and waste recycling. Whereas neurons are metabolically rigid, astrocytes can switch between different metabolic profiles according to local demand and the nutritional state of the organism. Their metabolic state even seems to be instructive for peripheral nutrient mobilization and has been implicated in information processing and behavior. Here, we summarize recent progress in our understanding of astrocytic metabolism and its effects on metabolic homeostasis and cognition.

Details

Original languageEnglish
Title of host publicationGlia
PublisherCold Spring Harbor Perspectives
Volume16
Publication statusPublished - 4 Mar 2024
Peer-reviewedYes

External IDs

Mendeley 98ff9e6d-6342-314b-8535-79a8a5841445
Scopus 85193941696

Keywords