The anti-inflammatory activities of Staphylococcus aureus

Research output: Contribution to journalReview articleContributedpeer-review


  • Triantafyllos Chavakis - , National Cancer Institute (NCI) (First author)
  • Klaus T. Preissner - , Justus Liebig University Giessen (Author)
  • Mathias Herrmann - , University Hospital of Saarland (Author)


Staphylococcus aureus is a versatile and harmful pathogen in both hospital- and community-associated infections that range from superficial to systemic infections. S. aureus engages a multitude of mechanisms to subvert the innate immune response of the host, including inhibition of complement activation and neutralization of anti-microbial peptides. In addition, inflammatory cell and phagocyte recruitment is an integral part of the innate defense to staphylococcal infection and comprises a well-coordinated multi-step cascade of adhesive events. Recent and rapidly growing experimental evidence indicates the existence of a machinery of anti-adhesive and anti-chemotactic moieties of S. aureus that allow the bacterium to interfere with specific adhesive steps of the homing mechanism of leukocytes. Understanding the functions of these S. aureus-derived anti-inflammatory agents could also provide the platform for designing new therapies in several inflammatory and autoimmune diseases.


Original languageEnglish
Pages (from-to)408-418
JournalTrends in Immunology
Issue number9
Publication statusPublished - Sept 2007
Externally publishedYes

External IDs

PubMed 17681885
Scopus 34548566416