Ten recently identified associations between nsSNPs and colorectal cancer could not be replicated in German families

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Bernd Frank - , German Cancer Research Center (DKFZ) (Author)
  • Barbara Burwinkel - , German Cancer Research Center (DKFZ) (Author)
  • Justo Lorenzo Bermejo - , German Cancer Research Center (DKFZ) (Author)
  • Asta Försti - , German Cancer Research Center (DKFZ), Karolinska Institutet (Author)
  • Kari Hemminki - , German Cancer Research Center (DKFZ), Karolinska Institutet (Author)
  • Richard Houlston - , Institute of Cancer Research (Author)
  • Elisabeth Mangold - , University of Bonn (Author)
  • Nils Rahner - , University of Bonn (Author)
  • Waltraut Friedl - , University of Bonn (Author)
  • Nicolaus Friedrichs - , University of Bonn (Author)
  • Reinhard Buettner - , University of Bonn (Author)
  • Christoph Engel - , Leipzig University (Author)
  • Markus Loeffler - , Leipzig University (Author)
  • Elke Holinski-Feder - , Ludwig Maximilian University of Munich (Author)
  • Monika Morak - , Ludwig Maximilian University of Munich (Author)
  • Gisela Keller - , Technical University of Munich (Author)
  • Hans K. Schackert - , Department of Surgical Research (Author)
  • Stefan Krüger - , Department of Surgical Research (Author)
  • Timm Goecke - , University Hospital Duesseldorf (Author)
  • Gabriela Moeslein - , Helios Hospital Group (Author)
  • Matthias Kloor - , Heidelberg University  (Author)
  • Johannes Gebert - , Heidelberg University  (Author)
  • Erdmute Kunstmann - , Ruhr University Bochum (Author)
  • Karsten Schulmann - , Ruhr University Bochum (Author)
  • Josef Rüschoff - , Klinikum Kassel GmbH (Author)
  • Peter Propping - , University of Bonn (Author)

Abstract

Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls. No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required.

Details

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalCancer letters
Volume271
Issue number1
Publication statusPublished - 18 Nov 2008
Peer-reviewedYes

External IDs

PubMed 18619730

Keywords

Sustainable Development Goals

ASJC Scopus subject areas

Keywords

  • Colorectal cancer risk, Non-synonymous single nucleotide polymorphisms, Replication studies