Temporary response of localized intracranial mast cell sarcoma to combination chemotherapy

Research output: Contribution to journal › Research article › Contributed › peer-review

Contributors

  • Philipp P. Guenther - , TUD Dresden University of Technology (Author)
  • Angela Huebner - , Department of Paediatrics, Department of Child and Adolescent Psychiatry and Psychotherapy , TUD Dresden University of Technology (Author)
  • Stephan B. Sobottka - , Department of Neurosurgery, TUD Dresden University of Technology (Author)
  • Volker Neumeister - , TUD Dresden University of Technology (Author)
  • Gerhard Weissbach - , TUD Dresden University of Technology (Author)
  • Horst Todt - , TUD Dresden University of Technology (Author)
  • Reza Parwaresch - , Kiel University (Author)

Abstract

Cerebral involvement of systemic mastocytosis and intracranial sarcoma of myelogenic origin are well known entities. An 8-year-old girl with an isolated cerebral mast cell tumor is presented. Specific histopathologic stains were used to confirm the diagnosis detecting immunophenotype and proliferative activity. Treatment with irradiation, intrathecal cytarabine, and interferon-α2b did not induce regression whereas polychemotherapy did. Systemic combination chemotherapy led to marked transient tumor regression in this proliferating mast cell sarcoma in an unusual intracranial location.

Details

Original languageEnglish
Pages (from-to)134-138
Number of pages5
Journal American journal of pediatric hematology - oncology
Volume23
Issue number2
Publication statusPublished - 2001
Peer-reviewedYes

External IDs

PubMed 11216707

Keywords

ASJC Scopus subject areas

Keywords

  • Brain, Chemotherapy, Granulocytic sarcoma, Interferon, Mastocytoma, Neoplasm, Neurosurgery, Radiotherapy, Systemic mast cell disease