Tailoring surface properties, biocompatibility and corrosion behavior of stainless steel by laser induced periodic surface treatment towards developing biomimetic stents

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

  • Muhammad Saqib - , Chair of Materials Science and Nanotechnology, Fraunhofer Institute for Ceramic Technologies and Systems, TUD Dresden University of Technology (Author)
  • Natalia Beshchasna - , Fraunhofer Institute for Ceramic Technologies and Systems (Author)
  • Riccardo Pelaccia - , University of Modena and Reggio Emilia (Author)
  • Anton Roshchupkin - , Sumy State University (Author)
  • Ilya Yanko - , Sumy State University (Author)
  • Yevheniia Husak - , Sumy State University, Silesian University of Technology (Author)
  • Sergiy Kyrylenko - , Sumy State University (Author)
  • Barbara Reggiani - , University of Modena and Reggio Emilia, Tecnopolo di Reggio Emilia (Author)
  • Gianaurelio Cuniberti - , Chair of Materials Science and Nanotechnology, TUD Dresden University of Technology (Author)
  • Maksym Pogorielov - , Sumy State University, University of Latvia, NanoPrime (Author)
  • Joerg Opitz - , Chair of Materials Science and Nanotechnology, Institute of Solid Mechanics, Fraunhofer Institute for Ceramic Technologies and Systems, TUD Dresden University of Technology (Author)
  • Leonardo Orazi - , University of Modena and Reggio Emilia, Tecnopolo di Reggio Emilia (Author)

Abstract

Laser-Induced Periodic Surface Structures (LIPSS) holds great potential for regenerative biomedicine. Creating highly precise LIPSS enables to generate biomimetic implant surfaces with improved properties. The present study focuses on the fabrication and investigation of laser-treated stainless steel samples with applied linear LIPSS patterns with grooves made by means of a picosecond laser system using wavelengths of 1064 nm and 532 nm. To investigate properties of the laser-treated surfaces and to understand the basics of cell-surface interactions between the LIPSS and human Umbilical Cord Mesenchymal Stem Cells (UCMSC), flat stainless steel samples with various applied nanopatterns were used. Such LIPSSs demonstrated higher surface roughness, good biocompatibility, lower wettability and higher corrosion resistance compared to the untreated (polished) specimens. The surface roughness of laser-treated samples was in microscale that enabled adhesion and migration of endothelial cells, thus increasing the likelihood for endothelialisation. This thereby could reduce the chances for the development of Late Stent Thrombosis (LST) and In-Stent Restenosis (ISR). Furthermore, laser textured surfaces demonstrated an environment supportive for cell attachment, proliferation and alignment with the nanogroves. Therefore, application of the biomimetic nanopatterns could help to overcome frequent post-surgery complications after the stent implantation.

Details

Original languageEnglish
Article number102365
JournalSurfaces and Interfaces
Volume34
Publication statusPublished - Nov 2022
Peer-reviewedYes

Keywords

Keywords

  • Biocompatibility, Cell orientation, Corrosion, Nanopatterns, Picosecond laser, Surface free energy, Surface roughness, Umbilical cord mesenchymal stem cells