Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion
Research output: Contribution to journal › Research article › Contributed › peer-review
Contributors
Abstract
POx bottle-brush brushes (BBBs) are synthesized by SIPGP of 2-isopropenyl-2-oxazoline and consecutive LCROP of 2-oxazolines on 3-aminopropyltrimethoxysilane-modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline). The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption.
Details
Original language | English |
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Pages (from-to) | 926-936 |
Number of pages | 11 |
Journal | Macromolecular bioscience |
Volume | 12 |
Issue number | 7 |
Publication status | Published - Jul 2012 |
Peer-reviewed | Yes |
External IDs
PubMed | 22610725 |
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ORCID | /0000-0003-0189-3448/work/162347637 |
Keywords
ASJC Scopus subject areas
Keywords
- Cell adhesion, Polymer brushes, Polyoxazolines, Protein adsorption, Surface-initiated polymerization