Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion

Research output: Contribution to journalResearch articleContributedpeer-review

Contributors

Abstract

POx bottle-brush brushes (BBBs) are synthesized by SIPGP of 2-isopropenyl-2-oxazoline and consecutive LCROP of 2-oxazolines on 3-aminopropyltrimethoxysilane-modified silicon substrates. The side chain hydrophilicity and polarity are varied. The impact of the chemical composition and architecture of the BBB upon protein (fibronectin) adsorption and endothelial cell adhesion are investigated and prove extremely low protein adsorption and cell adhesion on BBBs with hydrophilic side chains such as poly(2-methyl-2-oxazoline) and poly(2-ethyl-2-oxazoline). The influence of the POx side chain terminal function upon adsorption and adhesion is minor but the side chain length has a significant effect on bioadsorption.

Details

Original languageEnglish
Pages (from-to)926-936
Number of pages11
JournalMacromolecular bioscience
Volume12
Issue number7
Publication statusPublished - Jul 2012
Peer-reviewedYes

External IDs

PubMed 22610725
ORCID /0000-0003-0189-3448/work/162347637

Keywords

Keywords

  • Cell adhesion, Polymer brushes, Polyoxazolines, Protein adsorption, Surface-initiated polymerization